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首页> 外文OA文献 >Serum Levels Of Interleukin-6 (il-6), Interleukin-18 (il-18) And C-reactive Protein (crp) In Patients With Type-2 Diabetes And Acute Coronary Syndrome Without St-segment Elevation [níveis Séricos De Interleucina-6 (il-6), Interleucina-18 (il-18) E Proteína C Reativa (pcr) Na Síndrome Coronariana Aguda Sem Supradesnivelamento Do St Em Pacientes Com Diabete Tipo 2]
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Serum Levels Of Interleukin-6 (il-6), Interleukin-18 (il-18) And C-reactive Protein (crp) In Patients With Type-2 Diabetes And Acute Coronary Syndrome Without St-segment Elevation [níveis Séricos De Interleucina-6 (il-6), Interleucina-18 (il-18) E Proteína C Reativa (pcr) Na Síndrome Coronariana Aguda Sem Supradesnivelamento Do St Em Pacientes Com Diabete Tipo 2]

机译：2型糖尿病合并急性冠脉综合征且无​​分段节段升高的患者血清白细胞介素6（il-6），白细胞介素18（il-18）和C反应蛋白（crp）的水平[血清白细胞介素- 2型糖尿病患者无ST升高的急性冠脉综合征中6（il-6），白细胞介素18（il-18）和C反应蛋白（pcr）的表达]

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Background: Atherosclerosis is an inflammatory disease, and serum levels of inflammatory markers such as interleukin 6 (IL-6), interleukin 18 (IL-18) and C-reactive protein (CRP) are used to evaluate patients with coronary artery disease. In patients with type-2 diabetes, atherosclerosis is related to a larger number of events such as myocardial infarction and death, when compared with patients without diabetes. Objective: To evaluate the inflammatory response in patients with diabetes and acute events of coronary instability. Methods: Two groups of patients were primarily selected. The first group was comprised of diabetic outpatients with stable angina (D-CCS) and presence of coronary artery disease on coronary angiography (n=36). The second group was comprised of diabetic patients seen in the emergency room with acute coronary syndrome (D-ACS) without ST-segment elevation (n=38). Non-diabetic patients with ACS (n=22) and CCS (n=16) comprised the control group. Serum levels of CRP, IL-6 and IL-18 were determined using nephelometry (CRP) and ELISA (IL-6 and IL-18) techniques. Results: Higher serum IL-6 levels were found in diabetic or non-diabetic patients with ACS than in the group with CCS. On the other hand, diabetic patients with ACS had higher CRP levels in comparison with the other groups. Serum IL-18 levels were not significantly different among the patients studied. Conclusion: our findings suggest a more intense inflammatory activity in patients with coronary instability. This inflammatory activity, as measured by CRP, seems to be even more intense in diabetic patients.
机译：背景：动脉粥样硬化是一种炎症性疾病，血清中的炎症标记物（例如白介素6（IL-6），白介素18（IL-18）和C反应蛋白（CRP））的水平用于评估冠心病患者。与没有糖尿病的患者相比，在2型糖尿病患者中，动脉粥样硬化与大量事件（如心肌梗塞和死亡）有关。目的：评估糖尿病患者的炎症反应和冠状动脉不稳定的急性事件。方法：主要选择两组患者。第一组包括患有稳定型心绞痛（D-CCS）且在冠状动脉造影上存在冠状动脉疾病的糖尿病门诊患者（n = 36）。第二组包括在急诊室就诊的患有急性冠脉综合征（D-ACS）而无ST段抬高的糖尿病患者（n = 38）。对照组为ACS（n = 22）和CCS（n = 16）的非糖尿病患者。使用比浊法（CRP）和ELISA（IL-6和IL-18）技术测定血清CRP，IL-6和IL-18的水平。结果：糖尿病或非糖尿病ACS患者的血清IL-6水平高于CCS组。另一方面，患有ACS的糖尿病患者的CRP水平高于其他组。在研究的患者中，血清IL-18水平没有显着差异。结论：我们的发现提示冠状动脉不稳定患者的炎症活动更强烈。通过CRP测定的这种炎性活性在糖尿病患者中似乎更为强烈。

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